Dr Christine Denby
Nursing and Advanced Practice
Faculty of Health
Email: C.E.Denby@ljmu.ac.uk
ORCID
Christine is a HCPC registered Clinical Scientist, qualifying in 2014 after undergoing pre-registration and higher clinical scientist training in diagnostics and therapeutics (clinical and physiological measurement and Magnetic Resonance Imaging) at NHS University Hospitals of Liverpool Group (UHLG). Christine has previously held post-doctoral clinical research positions at the Universities of Liverpool and Manchester, focusing on neuroimaging.
In September 2024 Christine joined LJMU as a Senior Lecturer in the School of Nursing and Advanced Practice. Christine’s previous role was a principal clinical scientist at the Royal Liverpool Hospital, combined with being the head of teaching and training for medical physics and clinical engineering for NHS University Hospitals of Liverpool Group (UHLG) and led pre- and post-clinical scientist training on the Scientist Training Programme (STP) and Higher Specialist Scientist Training (HSST) in physiological measurement, clinical engineering, MRI, imaging and bioinformatics. Christine lectured on the Institute of Physics and Engineering in Medicine (IPEM) accredited MSc in Medical Physics/Clinical Science at the University of Liverpool from 2012-2024 and provided clinical supervision and work-based training to meet the requirements of HCPC registration as a Clinical Scientist in several specialisms. Christine also worked on clinical trials in neurology and cardiology, having a particular interest in epilepsy, stroke, angina and heart failure.
Current research interests are focused on advanced imaging techniques for investigating cardiovascular disease. Of particular interest is functional MRI (fMRI) in determining the neural correlates of angina pain and Magnetic Resonance Spectroscopy (31P MRS) for assessing cellular kinetics in heart failure. Christine also provides teaching, training and research support for the clinical endoscopist training programme.
Degrees
University of Manchester, United Kingdom, MSc Medical Physics
University of Liverpool, United Kingdom, PhD Neuroimaging
University of Manchester, United Kingdom, MSc Neuroscience
University of Liverpool, United Kingdom, BSc(hons) Physiology
Journal article
Mckavanagh A, Kreilkamp BAK, Chen Y, Denby C, Bracewell M, Das K, De Bezenac C, Marson AG, Taylor PN, Keller SS. 2022. Altered Structural Brain Networks in Refractory and Nonrefractory Idiopathic Generalized Epilepsy Brain Connectivity, 12 :549-560 DOI Author Url Publisher Url Public Url
Brownhill D, Chen Y, Kreilkamp BAK, de Bezenac C, Denby C, Bracewell M, Biswas S, Das K, Marson AG, Keller SS. 2021. Automated subcortical volume estimation from 2D MRI in epilepsy and implications for clinical trials Neuroradiology, 64 :935-947 DOI Author Url Publisher Url Public Url
Pegg EJ, Mckavanagh A, Bracewell RM, Chen Y, Das K, Denby C, Kreilkamp BAK, Laiou P, Marson A, Mohanraj R, Taylor JR, Keller SS. 2021. Functional network topology in drug resistant and well-controlled idiopathic generalized epilepsy: a resting state functional MRI study Brain Communications, 3 :1-12 DOI Author Url Publisher Url Public Url
Chen Y, Fallon N, Kreilkamp BAK, Denby C, Bracewell M, Das K, Pegg E, Mohanraj R, Marson AG, Keller SS. 2021. Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy Human Brain Mapping, 42 :5648-5664 DOI Author Url Publisher Url Public Url
Denby CE, Chatterjee K, Pullicino R, Lane S, Radon MR, Das KV. 2020. Is four-dimensional CT angiography as effective as digital subtraction angiography in the detection of the underlying causes of intracerebral haemorrhage: a systematic review Neuroradiology, 62 :273-281 DOI Author Url Publisher Url Public Url
S H, Al-Orainy A, Saldanha A, D W, Denby C, Pandit L, M B, A J. 2018. 289 MRI abnormalities in mog antibody disease Journal of Neurology, Neurosurgery & Psychiatry, 89 :A44.3-A45 DOI Publisher Url
Walker AMN, Patel PA, Rajwani A, Groves D, Denby C, Kearney L, Sapsford RJ, Witte KK, Kearney MT, Cubbon RM. 2016. Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction Diabetes and Vascular Disease Research, 13 :331-340 DOI Author Url Publisher Url Public Url
Cubbon RM, Ruff N, Groves D, Eleuteri A, Denby C, Kearney L, Ali N, Walker AMN, Jamil H, Gierula J, Gale CP, Batin PD, Nolan J, Shah AM, Fox KAA, Sapsford RJ, Witte KK, Kearney MT. 2015. Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure Heart, 102 :223-229 DOI Author Url Publisher Url Public Url
Denby C, Groves DG, Eleuteri A, Tsang HK, Leach A, Hammond C, Bridson JD, Fisher M, Elt M, Laflin R, Fisher AC. 2014. Temporary sympathectomy in chronic refractory angina: A randomised, double-blind, placebo-controlled trial British Journal of Pain, 9 :142-148 DOI Author Url Publisher Url
Edelstyn NMJ, Mayes AR, Denby C, Ellis SJ. 2012. Impairment in material-specific long-term memory following unilateral mediodorsal thalamic damage and presumed partial disconnection of the mammillo-thalamic tract Journal of Neuropsychology, 6 :119-140 DOI Author Url Publisher Url
Denby CE, Vann SD, Tsivilis D, Aggleton JP, Montaldi D, Roberts N, Mayes AR. 2009. The frequency and extent of mammillary body atrophy associated with surgical removal of a colloid cyst American Journal of Neuroradiology, 30 :736-743 DOI Author Url Publisher Url
Vann SD, Tsivilis D, Denby CE, Quamme JR, Yonelinas AP, Aggleton JP, Montaldi D, Mayes AR. 2009. Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods Proceedings of the National Academy of Sciences of the United States of America, 106 :5442-5447 DOI Author Url Publisher Url
Vann SD, Denby C, Love S, Montaldi D, Renowden S, Coakham HB. 2008. Memory Loss Resulting From Fornix and Septal Damage: Impaired Supra-Span Recall but Preserved Recognition Over a 24-Hour Delay Neuropsychology, 22 :658-668 DOI Author Url Publisher Url
Holdstock JS, Parslow DM, Morris RG, Fleminger S, Abrahams S, Denby C, Montaldi D, Mayes AR. 2008. Two case studies illustrating how relatively selective hippocampal lesions in humans can have quite different effects on memory Hippocampus, 18 :679-691 DOI Author Url Publisher Url
Tsivilis D, Vann SD, Denby C, Roberts N, Mayes AR, Montaldi D, Aggleton JP. 2008. A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory Nature Neuroscience, 11 :834-842 DOI Author Url Publisher Url
Keller SS, Cresswell P, Denby C, Wieshmann U, Eldridge P, Baker G, Roberts N. 2007. Persistent seizures following left temporal lobe surgery are associated with posterior and bilateral structural and functional brain abnormalities Epilepsy Research, 74 :131-139 DOI Author Url Publisher Url
García-Fiñana M, Denby CE, Keller SS, Wieshmann UC, Roberts N. 2006. Degree of hippocampal atrophy is related to side of seizure onset in temporal lobe epilepsy American Journal of Neuroradiology, 27 :1046-1052 Author Url
Aggleton JP, Vann SD, Denby C, Dix S, Mayes AR, Roberts N, Yonelinas AP. 2005. Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology Neuropsychologia, 43 :1810-1823 DOI Author Url Publisher Url
Bastin C, Van der Linden M, Charnallet A, Denby C, Montaldi D, Roberts N, Mayes AR. 2004. Dissociation between recall and recognition memory performance in an amnesic patient with hippocampal damage following carbon monoxide poisoning Neurocase, 10 :330-344 DOI Author Url Publisher Url
Wieshmann UC, Denby CE, Eldridge PR, Roberts N, Mackay CE, Webb JA, Tedman BM, Chadwick DW, Smith DF. 2003. Foramen ovale recordings: A presurgical investigation in epilepsy European Neurology, 49 :3-7 DOI Author Url Publisher Url
Keller SS, Wieshmann UC, Mackay CE, Denby CE, Webb J, Roberts N. 2002. Voxel based morphometry of grey matter abnormalities in patients with medically intractable temporal lobe epilepsy: Effects of side of seizure onset and epilepsy duration Journal of Neurology Neurosurgery and Psychiatry, 73 :648-656 DOI Author Url Publisher Url
External collaboration:
https://www.liverpoolft.nhs.uk/services/service-finder/cardiology, Liverpool University Hospitals NHS Foundation Trust (LUHFT), Professor Michael Fisher. 2024
https://mahse.co.uk/our-programmes/doctoral-level-hsst/, University of Manchester, Faculty of Biology, Medicine and Health Higher Specialist Scientist Training (HSST). 2022
https://www.liverpool.ac.uk/research/facilities/limric/, University of Liverpool, Liverpool Magnetic Resonance Imaging Centre (LiMRIC). 2003
Teaching qualification:
FHEA. 2022
Membership of professional bodies:
Clinical Scientist, The Health and Care Professions Council (HCPC), https://www.hcpc-uk.org/. 2014
Member of IPEM, Institute of Physics and Engineering in Medicine. 2008