Dr Alistair Fielding
Pharmacy and Biomolecular Sciences
Faculty of Science
Email: A.J.Fielding@ljmu.ac.uk
Telephone: 0151 231 2576
Bruker Applications Scientist/Senior Lecturer (2012-2017), University of Manchester, UK
DFG Fellowship (2008-2012), Max-Planck for Biophysical Chemistry, Goettingen, Germany
CEA Fellowship (2006-2008) at CEA-Saclay, France
Postdoctoral research Associate (2003-2006), University of Denver, USA
I am Senior Lecturer in Analytical Chemistry and Programme Leader for the MSc Drug Discovery, Development and Delivery within the School of Pharmacy and Biomolecular Sciences. The Fielding group uses electron paramagnetic resonance (EPR) spectroscopy to solve biological and material science problems concerning structure and transient intermediates. EPR is analogous to nuclear magnetic resonance (NMR) spectroscopy and measures unpaired electrons. EPR is particularly useful for studying metal complexes and organic radicals. The applications are broad, ranging from chemistry/pharmacy, materials science to sports science. The Fielding group’s research is wide-ranging and problem driven.
Research interests
Plastic Waste
We have recently successfully obtained a Leverhulme Fellowship (2019-2020) and a RSC Research Enablement Grant (2021-2022) for a project titled: “Understanding the radical source of the degradation of plastic waste”. The project aims to achieve a comprehensive understanding of the radical mechanism of action involved in the degradation of common plastic waste materials. We have done several media appearances on this subject and are happy to do more.
Industrial aspects of EPR
The objectives involve employing EPR and various spectroscopic methods to assess drug interactions within the industrial context.
Materials Science
We have a number of collaborations concerning novel carbon materials for energy devices. We have worked on the surface chemistry of graphene oxide using EPR (Fielding, A.J.* et al., Applied ACS Nano., 2019, 2, 19–27).
Structural Biology
Excitingly, we have developed a new synthetic strategy that uses spin labels to link biofunctional groups to surfaces (Fielding, A.J.* et al., A Bifunctional Spin Label for Ligand Recognition on Surfaces, Angewandte Chemie - International Edition 2017, 56, 9449-9453). This has been developed to create a new spin label using a three bond tether (Fielding, A.J.* et al., Applied Magnetic Resonance 2021) to be used to help understand conformational changes of proteins. Other expertise includes UV-vis stopped flow and rapid freeze-quench.
In all endeavours, we welcome collaborative partners both nationally and abroad. Phone calls always welcome.
Industrial EPR sample running is possible. LJMU has a Bruker EMX EPR instrument.
We work with several industrial companies concerning challenging analytical problems. We welcome enquiries.
We can be found on twitter: @Fielding_Group
PhD Students
Currently, seven students have gained their PhD under my supervision. All have gone on to careers in either academia or industry. New applications are always welcome.
Teaching
Analytical and physical chemistry. Topics include: NMR, EPR, AAS, ICP-OES, ICP-MS, IR, UV-vis, electrochemistry, Group Theory and transition metal spectroscopy.
Highlighted publications
Dale JJ, Stanley J, Dop RA, Chronowska-Bojczuk G, Fielding AJ, Neill DR, Hasell T. 2023. Exploring inverse vulcanisation mechanisms from the perspective of dark sulfur European Polymer Journal, 195 DOI Publisher Url Public Url
Heaven G, Hollas MA, Tabernero L, Fielding AJ. 2021. Spin Labeling of Surface Cysteines Using a Bromoacrylaldehyde Spin Label Applied Magnetic Resonance, DOI Author Url Publisher Url Public Url
Wang B, Fielding AJ, Dryfe RAW. 2018. Electron Paramagnetic Resonance Investigation of the Structure of Graphene Oxide: pH-Dependence of the Spectroscopic Response ACS Applied Nano Materials, 2 :19-27 DOI Author Url Publisher Url Public Url
Hollas MA, Webb SJ, Flitsch SL, Fielding AJ. 2017. A Bifunctional Spin Label for Ligand Recognition on Surfaces. Angewandte Chemie International Edition, 56 :9449-9453 DOI Author Url Publisher Url Public Url
Journal article
Wang B, Teng X, Li X, Fielding AJ, Wang W, Liu H, Zhao Z, Li Y, Iamprasertkun P, Yang L, Ruiz NT, Li Q, Wu M, Hu H. 2024. Spin Charge of Co Nanoparticles Loaded on the Carbon Substrate Enabling Rate-Capable Lithium Storage at High Mass-Loadings Advanced Functional Materials, DOI Publisher Url Public Url
Solaja OM, Fielding A, Awobona S. 2024. Examining socio-demographics and understanding business factors among plastic bottle waste collectors in Ogun state, Nigeria Recycling and Sustainable Development, 17 :1-18 DOI Publisher Url Public Url
Wang B, Fitzpatrick JR, Brookfield A, Fielding A, Reynolds E, Entwistle J, Tong J, Spencer BF, Baldock S, Hunter K, Kavanagh CM, Tapia-Ruiz N. 2024. Electron paramagnetic resonance as a tool to determine the sodium charge storage mechanism of hard carbon Nature Communications, 15 :1-14 DOI Author Url Publisher Url Public Url
Prieto JM, Fielding A, Ismail F, Nakouti I, Ehtezazi T, Rahman P, Fatokun AA, Ritchie KJ, Sarker SD. 2024. RESEARCH ACTIVITIES IN THE CENTRE FOR NATURAL PRODUCTS DISCOVERY IN 2023 Journal of Natural Products Discovery, 2 :1-6 DOI
Veloso AD, Ferraria AM, Botelho do Rego AM, Viana AS, Fernandes AJS, Fielding AJ, Videira RA, Oliveira MC. 2023. Structural effects induced by dialysis-based purification of carbon nanomaterials Nano Materials Science, 6 :475-483 DOI Publisher Url Public Url
Taiwo BJ, Miller AH, Fielding AJ, Sarker SD, van Heerden FR, Fatokun AA. 2023. Ceibinin, a new positional isomer of mangiferin from the inflorescence of Ceiba pentandra (Bombacaceae), elicits similar antioxidant effect but no anti-inflammatory potential compared to mangiferin Heliyon, 10 :1-11 DOI Author Url Publisher Url Public Url
Dale JJ, Stanley J, Dop RA, Chronowska-Bojczuk G, Fielding AJ, Neill DR, Hasell T. 2023. Exploring inverse vulcanisation mechanisms from the perspective of dark sulfur European Polymer Journal, 195 DOI Publisher Url Public Url
Miller AH, Nguyen HTT, Nery JG, Fielding AJ. 2023. Electrochemical sensor based on epoxy-functionalized BEA nanozeolite and graphene oxide modified glassy carbon electrode for bisphenol E determination Journal of Applied Electrochemistry, DOI Publisher Url Public Url
Fielding A. 2022. Applications of Electron Paramagnetic Resonance Spectroscopy in Natural Product Research Journal of Natural Products Discovery, 1 DOI Publisher Url Public Url
Freeman SL, Skafar V, Kwon H, Fielding AJ, Moody PCE, Martínez A, Issoglio FM, Inchausti L, Smircich P, Zeida A, Piacenza L, Radi R, Raven EL. 2022. Crystal structure of Trypanosoma cruzi heme peroxidase and characterization of its substrate specificity and compound I intermediate Journal of Biological Chemistry, 298 DOI Author Url Publisher Url Public Url
Kelly-Hunt AE, Mehan A, Brooks S, Leanca MA, McKay JED, Mahamed N, Lambert D, Dempster NM, Allen RJ, Evans AR, Sarker SD, Nahar L, Sharples GP, Drew MGB, Fielding AJ, Ismail FMD. 2021. Synthesis and Analytical Characterization of Purpurogallin: A Pharmacologically Active Constituent of Oak Galls Journal of Chemical Education, DOI Author Url Publisher Url Public Url
Miller AH, de Vasconcellos A, Fielding AJ, Nery JG. 2021. Nanozeolites as support for laccase immobilization: Application to mediated glycerol oxidation Applied Catalysis A: General, 626 DOI Author Url Publisher Url Public Url
Watson HA, Fielding AJ, Hale KJ. 2021. EPR evidence for alpha-triphenylstannylvinyl radicals in the O-directed hydrostannation of dialkylacetylenes with Ph3SnH/cat. Et3B/O-2 Chemical communications (Cambridge, England), 57 :7449-7452 DOI Author Url Publisher Url Public Url
Heaven G, Hollas MA, Tabernero L, Fielding AJ. 2021. Spin Labeling of Surface Cysteines Using a Bromoacrylaldehyde Spin Label Applied Magnetic Resonance, DOI Author Url Publisher Url Public Url
Kwon H, Basran J, Pathak C, Hussain M, Freeman SL, Fielding AJ, Bailey AJ, Stefanou N, Sparkes HA, Tosha T, Yamashita K, Hirata K, Murakami H, Ueno G, Ago H, Tono K, Yamamoto M, Sawai H, Shiro Y, Sugimoto H, Raven EL, Moody PCE. 2021. XFEL Crystal Structures of Peroxidase Compound II. Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 133 :14699-14706 DOI Author Url Publisher Url
Kwon H, Basran J, Pathak C, Hussain M, Freeman SL, Fielding AJ, Bailey AJ, Stefanou N, Sparkes HA, Tosha T, Yamashita K, Hirata K, Murakami H, Ueno G, Ago H, Tono K, Yamamoto M, Sawai H, Shiro Y, Sugimoto H, Raven EL, Moody PCE. 2021. XFEL Crystal Structures of Peroxidase Compound II. Angewandte Chemie International Edition, DOI Author Url Publisher Url Public Url
Bowman M, Fielding A, Tseytlin M. 2021. Gareth R. Eaton: On the Occasion of His 80th Birthday APPLIED MAGNETIC RESONANCE, 52 :903-905 DOI Author Url Publisher Url
Costa SIR, Choi Y-S, Fielding AJ, Naylor AJ, Griffin JM, Sofer Z, Scanlon DO, Tapia Ruiz N. 2020. Surface engineering strategy using urea to improve the rate performance of Na2Ti3O7 in Na-ion batteries. Chemistry: A European Journal, DOI Author Url Publisher Url Public Url
Lockyer SJ, Nawaz S, Brookfield A, Fielding AJ, Vitorica-Yrezabal IJ, Timco GA, Burton NA, Bowen AM, Winpenny REP, McInnes EJL. 2020. Conformational Flexibility of Hybrid [3]- and [4]-Rotaxanes Journal of the American Chemical Society, 142 :15941-15949 DOI Author Url Publisher Url Public Url
Wang B, Likodimos V, Fielding AJ, Dryfe RAW. 2019. In situ Electron Paramagnetic Resonance Spectroelectrochemical Study of Graphene-based Supercapacitors: Comparison between Chemically Reduced Graphene Oxide and Nitrogen-doped Reduced Graphene Oxide Carbon, 160 :236-246 DOI Author Url Publisher Url Public Url
Freeman SL, Kwon H, Portolano N, Parkin G, Venkatraman Girija U, Basran J, Fielding AJ, Fairall L, Svistunenko DA, Moody PCE, Schwabe JWR, Kyriacou CP, Raven EL. 2019. Heme binding to human CLOCK affects interactions with the E-box. Proceedings of the National Academy of Sciences, 40 :19911-19916 DOI Author Url Publisher Url Public Url
Lockyer SJ, Fielding AJ, Whitehead GFS, Timco GA, Winpenny REP, McInnes EJL. 2019. Close Encounters of the Weak Kind: Investigations of Electron-Electron Interactions between Dissimilar Spins in Hybrid Rotaxanes. Journal of the American Chemical Society, 141 :14633-14642 DOI Author Url Publisher Url Public Url
Wang B, Fielding AJ, Dryfe RAW. 2019. Electron Paramagnetic Resonance as a Structural Tool to Study Graphene Oxide: Potential Dependence of the EPR Response The Journal of Physical Chemistry C, DOI Author Url Publisher Url Public Url
Fernandez-Soto A, Bruce A, Fielding AJ, Cavet J, Tabernero L. 2019. Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs. Scientific Reports, 9 DOI Author Url Publisher Url Public Url
Moro F, Fielding AJ, Turyanska L, Patanè A. 2019. Realization of Universal Quantum Gates with Spin-Qudits in Colloidal Quantum Dots Advanced Quantum Technologies, DOI Author Url Publisher Url Public Url
Lukinović V, Woodward JR, Marrafa TC, Shanmugam M, Heyes DJ, Hardman SJO, Scrutton NS, Hay S, Fielding A, Jones AR. 2019. Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, DOI Author Url Publisher Url Public Url
Wang B, Fielding AJ, Dryfe RAW. 2018. Electron Paramagnetic Resonance Investigation of the Structure of Graphene Oxide: pH-Dependence of the Spectroscopic Response ACS Applied Nano Materials, 2 :19-27 DOI Author Url Publisher Url Public Url
Del Casino A, Lukinović V, Bhatt R, Randle LE, Dascombe MJ, Fennell BJ, Drew MGB, Bell A, Fielding AJ, Ismail FMD. 2018. Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials ChemistrySelect, 26 :7572-7580 DOI Author Url Publisher Url Public Url
Moro F, Bhuiyan MA, Kudrynskyi ZR, Puttock R, Kazakova O, Makarovsky O, Fay MW, Parmenter C, Kovalyuk ZD, Fielding AJ, Kern M, van Slageren J, Patanè A. 2018. Room Temperature Uniaxial Magnetic Anisotropy Induced By Fe‐Islands in the InSe Semiconductor Van Der Waals Crystal Advanced Science, DOI Author Url Publisher Url Public Url
Brownbill NJ, Sprick RS, Bonillo B, Pawsey S, Aussenac F, Fielding AJ, Cooper AI, Blanc F. 2018. Structural Elucidation of Amorphous Photocatalytic Polymers from Dynamic Nuclear Polarization Enhanced Solid State NMR Macromolecules, 51 :3088-3096 DOI Author Url Publisher Url Public Url
Wang B, Fielding AJ, Dryfe RAW. 2018. In situ electrochemical electron paramagnetic resonance spectroscopy as a tool to probe electrical double layer capacitance Chemical Communications, 54 :3827-3830 DOI Author Url Publisher Url Public Url
Gonzalez JR, Alcantara R, Tirado JL, Fielding AJ, Dryfe RAW. 2017. Electrochemical Interaction of Few-Layer Molybdenum Disulfide Composites vs Sodium: New Insights on the Reaction Mechanism Chemistry of Materials, 29 :5886-5895 DOI Author Url Publisher Url Public Url
Hollas MA, Webb SJ, Flitsch SL, Fielding AJ. 2017. A Bifunctional Spin Label for Ligand Recognition on Surfaces. Angewandte Chemie International Edition, 56 :9449-9453 DOI Author Url Publisher Url Public Url
Fielding AJ, Evans PG, Alizadeh S, Bisby R, Drew MGB, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Cantú Reinhard FG, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines Chemistry - A European Journal, DOI Author Url Publisher Url Public Url
Boulon M, Fernandez A, Moreno Pineda E, Chilton NF, Timco G, Fielding AJ, Winpenny REP. 2017. Measuring Spin⋅⋅⋅Spin Interactions between Heterospins in a Hybrid [2]Rotaxane Angewandte Chemie, 129 :3934-3937 DOI Publisher Url
Boulon ME, Fernandez A, Moreno Pineda E, Chilton NF, Timco G, Fielding AJ, Winpenny REP. 2017. Measuring Spin⋅⋅⋅Spin Interactions between Heterospins in a Hybrid [2]Rotaxane Angewandte Chemie International Edition, 56 :3876-3879 DOI Author Url Publisher Url Public Url
Park SS, Hendon CH, Fielding AJ, Walsh A, O'Keeffe M, Dinca M. 2017. The Organic Secondary Building Unit: Strong Intermolecular pi Interactions Define Topology in MIT-25, a Mesoporous MOF with Proton-Replete Channels Journal of the American Chemical Society, 139 :3619-3622 DOI Author Url Publisher Url Public Url
Brandariz-de-Pedro G, Heyes DJ, Hardman SJO, Shanmugam M, Jones AR, Weber S, Nohr D, Scrutton NS, Fielding AJ. 2017. Direct Evidence of an Excited-State Triplet Species upon Photoactivation of the Chlorophyll Precursor Protochlorophyllide Journal of Physical Chemistry Letters, 8 :1219-1223 DOI Author Url Publisher Url Public Url
Burgess SG, Grazia Concilio M, Bayliss R, Fielding AJ. 2016. Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy ChemistryOpen, 5 :531-534 DOI Author Url Publisher Url Public Url
Kwon H, Basran J, Casadei CM, Fielding AJ, Schrader TE, Ostermann A, Devos JM, Aller P, Blakeley MP, Moody PCE, Raven EL. 2016. Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme Nature Communications, 7 DOI Author Url Publisher Url Public Url
Gahloth D, Levy C, Heaven G, Stefani F, Wunderley L, Mould P, Cliff M, Bella J, Fielding AJ, Woodman P, Tabernero L. 2016. Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1 Structure, 24 :2115-2126 DOI Author Url Publisher Url Public Url
Moro F, Turyanska L, Wilman J, Williams HEL, Fielding AJ, Patanè A. 2016. Surface Sensing of Quantum Dots by Electron Spins Nano Letters, 16 :6343-6348 DOI Author Url Publisher Url Public Url
Parey K, Fielding AJ, Sörgel M, Rachel R, Huber H, Ziegler C, Rajendran C. 2016. In meso crystal structure of a novel membrane-associated octaheme cytochrome c from the Crenarchaeon Ignicoccus hospitalis The FEBS Journal, 283 :3807-3820 DOI Author Url Publisher Url Public Url
Fielding AJ, Concilio MG, Heaven G, Hollas MA. 2016. ChemInform Abstract: New Developments in Spin Labels for Pulsed Dipolar EPR ChemInform, 47 DOI Publisher Url
Concilio MG, Fielding AJ, Bayliss R, Burgess SG. 2016. Density functional theory studies of MTSL nitroxide side chain conformations attached to an activation loop Theoretical Chemistry Accounts, 135 DOI Author Url Publisher Url Public Url
Loughrey JJ, Patmore NJ, Baldansuren A, Fielding AJ, McInnes EJL, Hardie MJ, Sproules S, Halcrow MA. 2015. Platinum( ii ) complexes of mixed-valent radicals derived from cyclotricatechylene, a macrocyclic tris-dioxolene Chemical Science, 6 :6935-6948 DOI Author Url Publisher Url Public Url
Ardavan A, Bowen AM, Fernandez A, Fielding AJ, Kaminski D, Moro F, Muryn CA, Wise MD, Ruggi A, McInnes EJL, Severin K, Timco GA, Timmel CR, Tuna F, Whitehead GFS, Winpenny REP. 2015. Engineering coherent interactions in molecular nanomagnet dimers Quantum Information, 1 DOI Author Url Publisher Url Public Url
Moro F, Turyanska L, Wilman J, Fielding AJ, Fay MW, Granwehr J, Patanè A. 2015. Electron spin coherence near room temperature in magnetic quantum dots Scientific Reports, 5 DOI Author Url Publisher Url Public Url
Murray AT, Dowley MJH, Pradaux‐Caggiano F, Baldansuren A, Fielding AJ, Tuna F, Hendon CH, Walsh A, Lloyd‐Jones GC, John MP, Carbery DR. 2015. Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B Angewandte Chemie, 127 :9125-9128 DOI Publisher Url
Murray AT, Dowley MJH, Pradaux-Caggiano F, Baldansuren A, Fielding AJ, Tuna F, Hendon CH, Walsh A, Lloyd-Jones GC, John MP, Carbery DR. 2015. Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B Angewandte Chemie-International Edition, 54 :8997-9000 DOI Author Url Publisher Url Public Url
Fielding A, Concilio M, Heaven G, Hollas M. 2014. New Developments in Spin Labels for Pulsed Dipolar EPR Molecules, 19 :16998-17025 DOI Author Url Publisher Url Public Url
Casadei CM, Gumiero A, Metcalfe CL, Murphy EJ, Basran J, Concilio MG, Teixeira SCM, Schrader TE, Fielding AJ, Ostermann A, Blakeley MP, Raven EL, Moody PCE. 2014. Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase Science, 345 :193-197 DOI Author Url Publisher Url Public Url
Pievo R, Angerstein B, Fielding AJ, Koch C, Feussner I, Bennati M. 2013. A Rapid Freeze-Quench Setup for Multi-Frequency EPR Spectroscopy of Enzymatic Reactions CHEMPHYSCHEM, 14 :4094-4101 DOI Author Url Publisher Url
Fielding AJ, Parey K, Ermler U, Scheller S, Jaun B, Bennati M. 2013. Advanced electron paramagnetic resonance on the catalytic iron-sulfur cluster bound to the CCG domain of heterodisulfide reductase and succinate: quinone reductase JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 18 :905-915 DOI Author Url Publisher Url
Koch C, Tria G, Fielding AJ, Brodhun F, Valerius O, Feussner K, Braus GH, Svergun DI, Bennati M, Feussner I. 2013. A structural model of PpoA derived from SAXS-analysis-Implications for substrate conversion BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1831 :1449-1457 DOI Author Url Publisher Url
Pudney CR, Lane RSK, Fielding AJ, Magennis SW, Hay S, Scrutton NS. 2013. Enzymatic Single-Molecule Kinetic Isotope Effects JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135 :3855-3864 DOI Author Url Publisher Url
Koch C, Fielding AJ, Brodhun F, Bennati M, Feussner I. 2012. Linoleic acid positioning in psi factor producing oxygenase A, a fusion protein with an atypical cytochrome P450 activity FEBS JOURNAL, 279 :1594-1606 DOI Author Url Publisher Url
Fielding AJ, Brodhun F, Koch C, Pievo R, Denysenkov V, Feussner I, Bennati M. 2011. Multifrequency Electron Paramagnetic Resonance Characterization of PpoA, a CYP450 Fusion Protein that Catalyzes Fatty Acid Dioxygenation JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133 :9052-9062 DOI Author Url Publisher Url
Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier J-B, Lecoq A, Thai R, Courcon M, Masson C, Dugave C, Genet R, Pernodet J-L, Gondry M. 2009. Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106 :7426-7431 DOI Author Url Publisher Url
Fielding AJ, Singh R, Boscolo B, Loewen PC, Ghibaudi EM, Ivancich A. 2008. Intramolecular Electron Transfer versus Substrate Oxidation in Lactoperoxidase: Investigation of Radical Intermediates by Stopped-Flow Absorption Spectrophotometry and (9−285 GHz) Electron Paramagnetic Resonance Spectroscopy Biochemistry, 47 :9781-9792 DOI Author Url Publisher Url
Fielding AJ, Usselman RJ, Watmough N, Simkovic M, Frerman FE, Eaton GR, Eaton SS. 2008. Electron spin relaxation enhancement measurements of interspin distances in human, porcine, and Rhodobacter electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) JOURNAL OF MAGNETIC RESONANCE, 190 :222-232 DOI Author Url Publisher Url
Usselman RJ, Fielding AJ, Frerman FE, Watmough NJ, Eaton GR, Eaton SS. 2008. Impact of mutations on the midpoint potential of the [4Fe-4S](+1,+2) cluster and on catalytic activity in electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) BIOCHEMISTRY, 47 :92-100 DOI Author Url Publisher Url
Sato H, Kathirvelu V, Fielding A, Blinco JP, Micallef AS, Bottle SE, Eaton SS, Eaton GR. 2007. Impact of molecular size on electron spin relaxation rates of nitroxyl radicals in glassy solvents between 100 and 300K MOLECULAR PHYSICS, 105 :2137-2151 DOI Author Url Publisher Url
Fielding AJ, Fox S, Millhauser GL, Chattopadhyay M, Kroneck PMH, Fritz G, Eaton GR, Eaton SS. 2006. Electron spin relaxation of copper(II) complexes in glassy solution between 10 and 120 K JOURNAL OF MAGNETIC RESONANCE, 179 :92-104 DOI Author Url Publisher Url
Fielding AJ, Carl PJ, Eaton GR, Eaton SS. 2005. Multifrequency EPR of four triarylmethyl radicals APPLIED MAGNETIC RESONANCE, 28 :231-238 DOI Author Url Publisher Url
Sato H, Tani A, Fielding AJ, Eaton SS, Eaton GR, Whitehead NE, Ikeya M. 2004. Spatial distribution and formation of nitrate radical NO32- in Antarctic calcitic evaporates APPLIED MAGNETIC RESONANCE, 26 :601-616 DOI Author Url Publisher Url
Fielding AJ, Franchi P, Roberts BP, Smits TM. 2002. EPR and computational studies of the formation and beta-scission of cyclic and acyclic dialkoxyalkyl radicals JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, :155-163 DOI Author Url Publisher Url
Fielding AJ, Roberts BP. 2001. ChemInform Abstract: Radical‐Chain Isomerization of Allyl Silyl Ethers to Silyl Enol Ethers in the Presence of Thiols as Polarity Reversal Catalysts. ChemInform, 32 DOI Publisher Url
Fielding AJ, Roberts BP. 2001. Radical-chain isomerisation of allyl silyl ethers to silyl enol ethers in the presence of thiols as polarity reversal catalysts TETRAHEDRON LETTERS, 42 :4061-4064 DOI Author Url Publisher Url
preprint
Shelford J, Burgess SG, Rostkova E, Richards MW, Tiede C, Fielding AJ, Daviter T, Tomlinson DC, Calabrese AN, Pfuhl M, Bayliss R, Royle SJ. 2024. Structural characterization and inhibition of the interaction between ch-TOG and TACC3 Cold Spring Harbor Laboratory DOI Publisher Url
Heras C, Reta D, Valero R, Albareda G, Chilton N, Fielding A, Moreira IDPR, Bofill JM, Lopez Calahorra F. 2019. Biradical Formation by Deprotonation in Thiazole-Derivatives: The Hidden Nature of Dasatinib American Chemical Society (ACS) DOI Publisher Url
Heras C, Reta D, Valero R, Albareda G, Chilton N, Fielding A, Moreira IDPR, Bofill JM, Lopez Calahorra F. 2019. Biradical Formation by Deprotonation in Thiazole-Derivatives: The Hidden Nature of Dasatinib American Chemical Society (ACS) DOI Publisher Url
Moro F, Fielding AJ, Turyanska L, Patanè A. 2019. Realization of Universal Quantum Gates with Spin-Qudits in Colloidal Quantum Dots DOI Author Url Publisher Url
Concilio MG, Fielding AJ, Bayliss R, Burgess SG. 2016. Density functional theory studies of MTSL nitroxide side chain conformations attached to an activation loop DOI Author Url Publisher Url
Concilio MG, Fielding AJ, Bayliss R, Burgess SG. 2015. MD and EPR studies of the structure and dynamics of the MTSL spin-labelled activation loop of the Aurora-A kinase DOI Author Url
Ardavan A, Bowen AM, Fernandez A, Fielding AJ, Kaminski D, Moro F, Muryn CA, Wise MD, Ruggi A, McInnes EJL, Severin K, Timco GA, Timmel CR, Tuna F, Whitehead GFS, Winpenny REP. 2015. Engineering coherent interactions in molecular nanomagnet dimers DOI Author Url
Conference publication
Fielding A. 2021. Selective spin labelling of surface cysteines using a bromoacrylaldehyde spin label The 54th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry
Fielding A. 2019. A Bifunctional Spin-label for Ligand Recognition on Surfaces Modern Development of Magnetic Resonance DOI Publisher Url
Fielding A. 2018. A Bifunctional Spin-label for Ligand Recognition on Surfaces 51st Annual International Meeting ESR Spectroscopy Group of the Royal Society of Chemistry
Tuna F, Baldansuren A, Brookfield A, Fielding A, Collison D. 2017. Using EPR for the study of mimetic catalytic reactions and model compounds JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 18th International Conference on Biological Inorganic Chemistry (ICBIC) 22 :S274-S274 Author Url
Ng N, Fielding A, Amaya E. 2017. The role and regulation of reactive oxygen species in Xenopus early development and tadpole tail regeneration MECHANISMS OF DEVELOPMENT, 18th International Congress of Developmental Biology 145 :S131-S132 DOI Author Url Publisher Url
Kwon H, Basran J, Fielding A, Schrader T, Ostermann A, Blakeley M, Moody P, Raven E. 2017. Structure of a heme peroxidase compound II ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes 253 Author Url
Fielding AJ, Bin Back D, Engler M, Baruah B, Crans DC, Eaton GR, Eaton SS. 2007. Electron Spin Lattice Relaxation of V(IV) Complexes in Glassy Solutions between 15 and 70 K Kustin K, Pessoa JC, Crans DC. VANADIUM: THE VERASTILE METAL, 5th International Symposium on Chemistry and Biological Chemistry of Vanadium 974 :364-375 Author Url
Eaton SS, Eaton GR, Fielding A. 2006. INOR 8-EPR characterization of V(IV) complexes with and without an oxo group ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 232 Author Url
Ismail FMD, Abduallah , Dempster, NM, Saleem IY. Definitive Geometry of Chloroquine-Haematin Interactions: Spectroscopic, Spectrometric and DFT Investigations The Science of Medicines, Pharm. Sci. 2001, 1st September, 2011, D DOI Publisher Url
Other invited event:
Member of the Habilitation jury, University of Lille, Examinateur for Nucleic acid-based architectures as viewed by and with unpaired electrons. 2024
Chemistry careers, Runcorn College, Chemistry career workshop. 2022
Chemistry Careers, Cardinal Heeman Catholic High School, Chemistry career workshop. 2022
Public engagement:
Public talk or lecture, Local adults, Science communication event, Co-organizer, Student Life Building, Shotgun Science II, The second event was well-received, providing a unique and dynamic platform for science communication. It facilitated natural, mutual exchanges of ideas and highlighted scientific disciplines that are often overlooked.. 2024
Public talk or lecture, Local adults and family groups, Science communication event, Co-organizer, Student life building, Shotgun Science, An interactive “speed-dating” style event between nine academics and rotating groups of 9 x 3-4 people, designed to communicate university research. 2023
External PGR examinations performed:
University of Manchester, PhD, Use of Advanced Magnetic Resonance Methods for the Study of Molecular Spin Qubits. 2024
University of Antwerp, PhD, An Advanced EPR Investigation of Copper Complexes in Catalysis. 2023
University of Manchester, PhD, Magnetic investigation of nano-sized materials incorporating 3d ion. 2023
University of St Andrews, PhD, New labels for DEER spectroscopy. 2019
Conference organisation:
Tetrapyrrole Discussion Group Meeting in Liverpool, Co-organiser. 2024
Research Grants Awarded:
Split-site Commonwealth Studentship, Polyaniline–Bismuth Ferrite Nanocomposite Photocatalyst Immobilized on Liquid Natural Rubber as Integrated Adsorbents-Photocatalyst for Removal of Ciprofloxacin Antibiotic, Grant value (£): 34880, Duration of research project: 12 months. 2023
Royal Society of Chemistry, Research Enablement Grant, Grant value (£): 10,000, Duration of research project: 1 year. 2022
Leverhulme Trust, Leverhulme Fellowship, Grant value (£): 42,352, Duration of research project: 15 months. 2019
Sao Paulo Research Foundation (FAPESP) Split-site Studentship, The use of a copper Protein for Glycerol Refinement in Brazil, Grant value (£): 19040, Duration of research project: 12 months. 2019
External committees:
Committee of the Liverpool Local RSC Section., Royal Society of Chemistry (RSC), Member. 2022
Other Professional Activity:
External Examiner for London Met. University for inorganic and analytical chemistry.. 2022
Honorary Research Associate, Institute of Ageing and Chronic Disease, University of Liverpool.
Industrial connections:
AstraZeneca, Alderley Park (15/09/16), Bespoke talk titled: Electron Paramagnetic Resonance Spectroscopy in Pharmaceutical Research, Development and Analysis. 2015
Teaching qualification:
HEA Fellowship. 2015
Membership of professional bodies:
Member of the International EPR Society, International EPR Society.
Member of the Royal Society of Chemistry, Royal Society of Chemistry.