Dr Garry McDowell
Pharmacy and Biomolecular Sciences
Faculty of Science
Email: G.McDowell@ljmu.ac.uk
Garry McDowell is Head of Subject for Biomedical Sciences, with specialist interest in Clinical Biochemistry. Dr McDowell has clinical expertise in clinical biochemistry, in particular endocrinology, and is an internationally recognised expert in biomarker research in acute cardiology and heart failure.
Dr McDowell's research interest is focused on the translational aspects of the development and clinical validation of biomarkers for diagnostic and/or prognostic testing in cardiology.
His research underpins specific clinical objectives:
1. Generating and validating accurate and timely diagnostics for acute coronary syndromes.
2. Improving the diagnosis of acute coronary syndromes and heart failure.
3. Improved understanding of the prognostic roles of cardiac biomarkers.
I am also committed to collaborating and participating in important collaborative studies and have recently contributed to studies in predicting thrombosis in patients undergoing chemotherapy for breast cancer. In addition, other projects have explored the therapeutic potential of novel therapeutic approaches.
Publications are in high impact factor journals, for example:
Heart
British Journal of Cancer
Resuscitation
Journal of American College of Cardiology.
The Liverpool region has some of the highest rates of cardiac disease in the UK. The Liverpool Centre for Cardiovascular Science (LCCS), was founded in 2019 to bring together academics and clinicians with the aim of improving cardiac health. LCCS brings together the academic and clinical expertise of University of Liverpool, Liverpool John Moores University, Liverpool Heart and Chest Hospital NHS Foundation Trust and Liverpool Health Partners.
PhD Projects
Dr McDowell would be interested in receiving applications from potential self-funded PhD students. Potential projects are in:
1. Improving the predictive value of biomarkers for acute coronary syndromes
2. Improving the specificity of biomarkers for heart failure diagnosis
3. Use of artificial intelligence in the diagnosis of cardiovascular disease as a mechanism to combine clinical features, examination findings and biomarkers for the diagnosis of acute coronary syndromes and heart failure
4. Nutraceuticals in cardiovascular disease.
Degrees
Queens University Belfast, United Kingdom, PhD
Academic appointments
Head of Subject for Biomedical Sciences, Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 2020 - present
Postgraduate training
Membership of Royal College of Pathologists (MRCPath), United Kingdom, Royal College of Pathologists, 1997 - 2003
Highlighted publications
Body R, Twerenbold R, Austin C, Boeddinghaus J, Almashali M, Nestelberger T, Morris N, Badertscher P, McDowell G, Wildi K, Moss P, Gimenez MR, Jarman H, Bigler N, Einemann R, Koechlin L, Pourmahram G, Todd J, Mueller C, Freemont A. 2019. Diagnostic accuracy of a high-sensitivity cardiac troponin assay with a single serum test in the emergency department Clinical Chemistry, 65 :1006-1014 DOI Author Url Publisher Url Public Url
Body R, Almashali M, Morris N, Moss P, Jarman H, Appelboam A, Parris R, Chan L, Walker A, Harrison M, Wootten A, McDowell G. 2019. Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay Heart, 105 :768-774 DOI Author Url Publisher Url Public Url
Body R, Carlton E, Sperrin M, Lewis PS, Burrows G, Carley S, McDowell G, Buchan I, Greaves K, Mackway-Jones K. 2017. Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid: Single biomarker re-derivation and external validation in three cohorts Emergency Medicine Journal, 34 :349-356 DOI Author Url Publisher Url Public Url
Journal article
Chen Y, Zhong Z, Gue Y, Banach M, McDowell G, Mikhailidis DP, Toth PP, Penson PE, Tomasik T, Windak A, Gierlotka M, Osadnik T, Kuras A, Miga M, Jozwiak J, Lip GYH. 2025. Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015) The Lancet Regional Health - Europe, 49 DOI Publisher Url
Chen Y, Yang Z, Liu Y, Gue Y, Zhong Z, Chen T, Wang F, McDowell G, Huang B, Lip GYH. 2024. Prognostic value of glycaemic variability for mortality in critically ill atrial fibrillation patients and mortality prediction model using machine learning Cardiovascular Diabetology, 23 DOI Author Url Publisher Url Public Url
Ortega-Martorell S, Olier I, Lip GYH. 2024. A European network to develop virtual twin technology for personalized stroke management in atrial fibrillation: the TARGET consortium European Heart Journal, DOI Author Url Publisher Url Public Url
Chen Y, Huang B, Calvert P, Liu Y, Gue Y, Gupta D, McDowell G, Azariah JL, Namboodiri N, Unni G, Balagopalan JP, Lip GYH, Gopalan BC, Jabir A, George Koshy A, Zachariah G, Shifas Babu M, Venugopal K, Punnose E, Natarajan KU, Joseph J, Ashokan Nambiar C, Mohanan PP, George R, Sajeev CG, Syam N, Roby A, Daniel R, Krishnakumar VV, Pillai AM, Joseph S, Mini GK, Koya SF, Eapen K, Ram R, Mathew C, Faizal A, Issac B, Renga S, Menon J, Harikrishna D, Suresh K, Nair T, Susanth SS, Kumar RA, Abilash TP, Sreekala P, Rajeev E, Raj A, Naik R, Rajalekshmi S, Gopinath A, Binu R, Chacko J, Iqbal PT, Sudhir NM, Sreedharan M, Balakrishnan N, Musthaffa M, Jayakumar B, George S, Kumar A, Mathew T, Pramod VK, Shaloob M, Chandy MP, Vinod KR, Das K, Ahamad ZS, Mathew P. 2024. Phenotypes of South Asian patients with atrial fibrillation and holistic integrated care management: cluster analysis of data from KERALA-AF Registry The Lancet Regional Health - Southeast Asia, 31 DOI Author Url Publisher Url Public Url
France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, Young CA, McDowell G, Buckley BJR. 2024. Vitamin D and Cardiovascular Outcomes in Multiple Sclerosis Multiple Sclerosis and Related Disorders, 92 DOI Author Url Publisher Url Public Url
Davies E, Buckley BJR, Austin P, Lip GYH, Oni L, McDowell G, Rao A. 2024. Routine cardiac biomarkers for the prediction of incident major adverse cardiac events in patients with Glomerulonephritis: A real-world analysis using a global federated database BMC Nephrology, 25 DOI Author Url Publisher Url Public Url
Liu X, Yang M, Lip GYH, McDowell G. 2024. Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review Biomedicines, 12 :1071 DOI Author Url Publisher Url Public Url
Chen Y, Gue Y, McDowell G, Gorog DA, Lip GYH. 2024. Impaired endogenous fibrinolysis status: a potential prognostic predictor in ischemic stroke Minerva Medica, 115 :364-379 DOI Author Url Publisher Url Public Url
Davies E, Chetwynd A, McDowell G, Rao A, Oni L. 2024. The current use of proteomics and metabolomics in glomerulonephritis: a systematic literature review Journal of Nephrology, DOI Author Url Publisher Url Public Url
Prokopidis K, Morwani-Mangnani J, McDowell G, Lip GYH, Venturelli M, Sankaranarayanan R, Isanejad M. 2024. Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis European Geriatric Medicine, DOI Author Url Publisher Url Public Url
Chen Y, Gue Y, Calvert P, Gupta D, McDowell G, Azariah JL, Namboodiri N, Bucci T, Jabir A, Tse HF, Chao T-F, Lip GYH, Bahuleyan CG, KERALA-AF Registry , APHRS-AF Registry Investigators . 2024. Predicting stroke in Asian patients with atrial fibrillation using machine learning: A report from the KERALA-AF registry, with external validation in the APHRS-AF registry Current Problems in Cardiology, 49 DOI Author Url Publisher Url Public Url
Mcdowell G, Buckley BJR, Austin P, Lip GYH, Rao A. 2024. Prediction of incident major adverse cardiac events in patients starting haemodialysis for end stage kidney disease, using clinical laboratory cardiac biomarkers - a real world analysis. EUROPEAN HEART JOURNAL, 45 DOI Publisher Url
Chen Y, Gerra LG, Gue YG, Mcdowell GM, Boriani GB, Zheng YLZ, Lip GYHL. 2024. Identifying at-risk patients for atrial high-rate episodes by machine learning EUROPEAN HEART JOURNAL, 45 DOI Publisher Url
Anwar N, Davies E, Devonald MA, Lip GY, Mcdowell G, Rao A. 2023. Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitors in Kidney Transplant Recipients: A Real-World Analysis Using a Global Federated Database Journal of the American Society of Nephrology, 34 :78-78 DOI Publisher Url
Bucci T, Sagris D, Harrison SL, Underhill P, Pastori D, Ntaios G, McDowell G, Buckley BJR, Lip GYH. 2023. C-reactive protein levels are associated with early cardiac complications or death in patients with acute ischemic stroke: a propensity-matched analysis of a global federated health from the TriNetX network Internal and Emergency Medicine, DOI Author Url Publisher Url Public Url
Proietti R, Rivera-Caravaca JM, López-Gálvez R, Harrison SL, Marín F, Underhill P, Shantsila E, McDowell G, Vinciguerra M, Davies R, Giebel C, Lane DA, Lip GYH. 2023. Cerebrovascular, Cognitive and Cardiac Benefits of SGLT2 Inhibitors Therapy in Patients with Atrial Fibrillation and Type 2 Diabetes Mellitus: Results from a Global Federated Health Network Analysis Journal of Clinical Medicine, 12 DOI Author Url Publisher Url Public Url
Harrison SL, Buckley BJR, Zheng Y, Hill A, Hlaing T, Davies R, Guo Y, Lane DA, Lip GYH, Choi S, Elsheikh S, Sagris D, Joddrell M, Alobaida M, McCarthy E, McCarthy E, Eustace I, Eustace I, Hoad K, Hoad SJK, Logantha SJRJ, McDowell G, Shantsila A, Gue Y, Isanejad M, Jones I, Isanejad M, Jones I. 2023. Evaluation of Huawei Smart Wearables for Detection of Atrial Fibrillation in Patients Following Ischaemic Stroke: The Liverpool-Huawei Stroke Study. American heart journal, 257 :103-110 DOI Author Url Publisher Url Public Url
Barrie A, McDowell G, Troup S. 2021. An investigation into the effect of potential confounding patient and treatment parameters on human embryo morphokinetics Fertility and Sterility, DOI Author Url Publisher Url Public Url
Victor K, Bangash F, Stylianidis V, Hancock J, Monaghan M, Piper S, Byrne J, McDowell G, Redwood S, McDonagh T, Prendergast B, Carr-White G. 2020. Mitral regurgitation in acute heart failure: prevalence and response to treatment European Heart Journal, 41 DOI Publisher Url
Body R, Twerenbold R, Austin C, Boeddinghaus J, Almashali M, Nestelberger T, Morris N, Badertscher P, McDowell G, Wildi K, Moss P, Gimenez MR, Jarman H, Bigler N, Einemann R, Koechlin L, Pourmahram G, Todd J, Mueller C, Freemont A. 2019. Diagnostic accuracy of a high-sensitivity cardiac troponin assay with a single serum test in the emergency department Clinical Chemistry, 65 :1006-1014 DOI Author Url Publisher Url Public Url
Body R, Almashali M, Morris N, Moss P, Jarman H, Appelboam A, Parris R, Chan L, Walker A, Harrison M, Wootten A, McDowell G. 2019. Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay Heart, 105 :768-774 DOI Author Url Publisher Url Public Url
Chauhan A, Lalor T, Watson S, Adams D, Farrah TE, Anand A, Kimmitt R, Mills NL, Webb DJ, Dhaun N, Kalla R, Adams A, Vatn S, Bonfliglio F, Nimmo E, Kennedy N, Ventham N, Vatn M, Ricanek P, Halfvarson J, Soderhollm J, Pierik M, Torkvist L, Gomollon F, Gut I, Jahnsen J, Satsangi J, Body R, Almashali M, McDowell G, Taylor P, Lacey A, Rees A, Dayan C, Lazarus J, Nelson S, Okosieme O, Corcoran D, Young R, Ciadella P, McCartney P, Bajrangee A, Hennigan B, Collison D, Carrick D, Shaukat A, Good R, Watkins S, McEntegart M, Watt J, Welsh P, Sattar N, McConnachie A, Oldroyd K, Berry C, Parks T, Auckland K, Mentzer AJ, Kado J, Mirabel MM, Kauwe JK, Robson KJ, Mittal B, Steer AC, Hill AVS, Akbar M, Forrester M, Virlan AT, Gilmour A, Wallace C, Paterson C, Reid D, Siebert S, Porter D, Liversidge J, McInnes I, Goodyear C, Athwal V, Pritchett J, Zaitoun A, Irving W, Guha IN, Hanley NA, Hanley KP, Briggs T, Reynolds J, Rice G, Bondet V, Bruce E, Crow Y, Duffy D, Parker B, Bruce I, Martin K, Pritchett J, Aoibheann Mullan M, Llewellyn J, Athwal V, Zeef L, Farrow S, Streuli C, Henderson N, Friedman S, Hanley N, Hanley KP. 2018. Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland. QJM : monthly journal of the Association of Physicians, 111 :920-924 DOI Author Url
Chauhan A, Lalor T, Watson S, Adams D, Farrah TE, Anand A, Kimmitt R, Mills NL, Webb DJ, Dhaun N, Kalla R, Adams A, Vatn S, Bonfliglio F, Nimmo E, Kennedy N, Ventham N, Vatn M, Ricanek P, Halfvarson J, Soderhollm J, Pierik M, Torkvist L, Gomollon F, Gut I, Jahnsen J, Satsangi J, Body R, Almashali M, McDowell G, Taylor P, Lacey A, Rees A, Dayan C, Lazarus J, Nelson S, Okosieme O, Corcoran D, Young R, Ciadella P, McCartney P, Bajrangee A, Hennigan B, Collison D, Carrick D, Shaukat A, Good R, Watkins S, McEntegart M, Watt J, Welsh P, Sattar N, McConnachie A, Oldroyd K, Berry C, Parks T, Auckland K, Mentzer AJ, Kado J, Mirabel MM, Kauwe JK, Robson KJ, Mittal B, Steer AC, Hill AVS, Akbar M, Forrester M, Virlan AT, Gilmour A, Wallace C, Paterson C, Reid D, Siebert S, Porter D, Liversidge J, McInnes I, Goodyear C, Athwal V, Pritchett J, Zaitoun A, Irving W, Guha IN, Hanley NA, Hanley KP, Briggs T, Reynolds J, Rice G, Bondet V, Bruce E, Crow Y, Duffy D, Parker B, Bruce I, Martin K, Aoibheann Mullan M, Llewellyn J, Zeef L, Farrow S. 2018. Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland QJM : monthly journal of the Association of Physicians, 111 :920-924 DOI Author Url Publisher Url
Slevin M, Iemma RS, Zeinolabediny Y, Liu D, Ferris GR, Caprio V, Phillips N, Di Napoli M, Guo B, Zeng X, AlBaradie R, Binsaleh NK, McDowell G, Fang WH. 2018. Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic? Frontiers in Immunology, 9 :2124-2124 DOI Author Url Publisher Url Public Url
Almashali M, McDowell G, Morris N, Body R. 2018. P821Absolute and relative changes (delta) cardiac troponin I using a contemporary point of care assay for early diagnosis of myocardial infarction European Heart Journal, 39 DOI Publisher Url
Stout M, McDowell G, Pearce K, Garnett H. 2018. P6476Multi-layer and segmental longitudinal strain response to incremental cycle exercise European Heart Journal, 39 DOI Publisher Url
Body R, Almashali M, McDowell G, group BEOSTS. 2017. P1124Rapid acute myocardial infarction rule-out using the limit of detection of a point of care troponin assay: early results of the Bedside Evaluation of Sensitive Troponin (BEST) study European Heart Journal, 38 :ehx502.p1124 DOI
Barrie A, Homburg R, McDowell G, Brown J, Kingsland C, Troup S. 2017. Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis Human Fertility, 20 :179-185 DOI Author Url Publisher Url Public Url
Body R, Carlton E, Sperrin M, Lewis PS, Burrows G, Carley S, McDowell G, Buchan I, Greaves K, Mackway-Jones K. 2017. Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid: Single biomarker re-derivation and external validation in three cohorts Emergency Medicine Journal, 34 :349-356 DOI Author Url Publisher Url Public Url
Barrie A, Homburg R, McDowell G, Brown J, Kingsland C, Troup S. 2017. Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotypes assessed using time-lapse imaging Reproductive Biomedicine Online, 34 :455-462 DOI Author Url Publisher Url Public Url
Barrie A, Homburg R, McDowell G, Brown J, Kingsland C, Troup S. 2017. Examining the efficacy of six published time-lapse imaging embryo selection algorithms to predict implantation to demonstrate the need for the development of specific, in-house morphokinetic selection algorithms Fertility and Sterility, 107 :613-621 DOI Author Url Publisher Url Public Url
Body R, McDowell G. 2017. The Rise and Fall of Cardiac Troponin T CLINICAL CHEMISTRY, 63 :437-437 DOI Author Url Publisher Url
Al Mashali M, Morris N, McDowell G, Body R. 2016. The interobserver reliability of a novel qualitative point of care assay for heart-type fatty acid binding protein Clinical Biochemistry, 49 :1199-1201 DOI Author Url Publisher Url Public Url
Fang WH, Kumar S, McDowell G, Smith D, Krupinski J, Olah P, Al-Baradie RS, Al-Rukban MO, Petcu EB, Slevin M. 2016. Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells Stem Cells International, 2016 DOI Author Url Publisher Url Public Url
Kirwan CC, McCollum CN, McDowell G, Byrne GJ. 2015. Investigation of Proposed Mechanisms of Chemotherapy-Induced Venous Thromboembolism: Endothelial Cell Activation and Procoagulant Release Due to Apoptosis CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 21 :420-427 DOI Author Url Publisher Url
Body R, Carley S, McDowell G, Pemberton P, Burrows G, Cook G, Lewis PS, Smith A, MacKway-Jones K. 2014. The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: Derivation and external validation Heart, 100 :1462-1468 DOI Author Url Publisher Url
Slevin M, Baldellou M, Hill E, Alexander Y, McDowell G, Murgatroyd C, Carroll M, Degens H, Krupinski J, Rovira N, Chowdhury M, Serracino-Inglott F, Badimon L. 2014. Novel methods for accurate identification, isolation, and genomic analysis of symptomatic microenvironments in atherosclerotic arteries Methods in Molecular Biology, 1135 :289-305 DOI Author Url
Slevin M, Ahmed N, Wang Q, McDowell G, Badimon L. 2012. Unique vascular protective properties of natural products: Supplements or future main-line drugs with significant anti-atherosclerotic potential? Vascular Cell, 4 DOI Author Url Publisher Url
Body R, Carley S, McDowell G, Jaffe AS, France M, Cruickshank K, Wibberley C, MacKway-Jones K. 2012. Reply Journal of the American College of Cardiology, 59 :1571-1572 DOI Publisher Url
Farkouh ME. 2012. High-sensitivity troponin < 3 ng/L ruled out acute myocardial infarction ANNALS OF INTERNAL MEDICINE, 156 DOI Author Url Publisher Url
Coufopoulos A, McDowell G, Roe B, Maden M. 2012. Interventions to improve nutrition and nutrition related health amongst homeless mothers and their children: a systematic review PROCEEDINGS OF THE NUTRITION SOCIETY, 71 :E161-E161 DOI Publisher Url
McDowell G, Slevin M, Krupinski J. 2011. Nanotechnology for the treatment of coronary in stent restenosis: A clinical perspective Vascular Cell, 3 DOI Author Url Publisher Url
Body R, Carley S, McDowell G, Jaffe AS, France M, Cruickshank K, Wibberley C, Nuttall M, Mackway-Jones K. 2011. Rapid Exclusion of Acute Myocardial Infarction in Patients With Undetectable Troponin Using a High-Sensitivity Assay JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58 :1333-1339 DOI Author Url Publisher Url
Body R, McDowell G, Carley S, Wibberley C, Ferguson J, Mackway-Jones K. 2011. A FABP-ulous 'rule out' strategy? Heart fatty acid binding protein and troponin for rapid exclusion of acute myocardial infarction RESUSCITATION, 82 :1041-1046 DOI Author Url Publisher Url
Body R, Pemberton P, Ali F, McDowell G, Carley S, Smith A, Mackway-Jones K. 2011. Low soluble P-selectin may facilitate early exclusion of acute myocardial infarction CLINICA CHIMICA ACTA, 412 :614-618 DOI Author Url Publisher Url
Kirwan CC, Mcdowell G, Mccollum CN, Byrne GJ. 2011. Incidence of Venous Thromboembolism during Chemotherapy for Breast Cancer: Impact on Cancer Outcome ANTICANCER RESEARCH, 31 :2383-2388 Author Url
Body R, Carley S, Wibberley C, McDowell G, Ferguson J, Mackway-Jones K. 2010. The value of symptoms and signs in the emergent diagnosis of acute coronary syndromes RESUSCITATION, 81 :281-286 DOI Author Url Publisher Url
Griffith CA, Owen LJ, Body R, McDowell G, Keevil BG. 2010. Development of a method to measure plasma and whole blood choline by liquid chromatography tandem mass spectrometry ANNALS OF CLINICAL BIOCHEMISTRY, 47 :56-61 DOI Author Url Publisher Url
Body R, McDowell G, Carley S, Ferguson J, Mackway-Jones K. 2010. Diagnosing acute myocardial infarction with troponins: how low can you go? EMERGENCY MEDICINE JOURNAL, 27 :292-296 DOI Author Url Publisher Url
Kirwan CC, Byrne GJ, Kumar S, McDowell G. 2009. Platelet release of Vascular Endothelial Growth Factor (VEGF) in patients undergoing chemotherapy for breast cancer. Journal of angiogenesis research, 1 :7 DOI Author Url Publisher Url
Body R, Griffith CA, Keevil B, McDowell G, Carley S, Ferguson J, Mackway-Jones K. 2009. Choline for diagnosis and prognostication of acute coronary syndromes in the Emergency Department CLINICA CHIMICA ACTA, 404 :89-94 DOI Author Url Publisher Url
Body R, Carley S, McDowell G, Ferguson J, Mackway-Jones K. 2009. Can a modified thrombolysis in myocardial infarction risk score outperform the original for risk stratifying emergency department patients with chest pain? EMERGENCY MEDICINE JOURNAL, 26 :95-99 DOI Author Url Publisher Url
Chrysochou C, Manzoor S, Wright J, Roberts SA, Wood G, McDowell G, Kalra PA. 2009. Role of Renal Function and Cardiac Biomarkers (NT-proBNP and Troponin) in Determining Mortality and Cardiac Outcome in Atheromatous Renovascular Disease KIDNEY & BLOOD PRESSURE RESEARCH, 32 :373-379 DOI Author Url Publisher Url
Body R, McDowell G, Carley S, Mackway-Jones K. 2008. Do risk factors for chronic coronary heart disease help diagnose acute myocardial infarction in the Emergency Department? RESUSCITATION, 79 :41-45 DOI Author Url Publisher Url
Kirwan CC, McDowell G, McCollum CN, Kumar S, Byrne GJ. 2008. Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer BRITISH JOURNAL OF CANCER, 99 :1000-1006 DOI Author Url Publisher Url
Summers CW, Pumphrey RS, Woods CN, McDowell G, Pemberton PW, Arkwright PD. 2008. Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 121 :632-638 DOI Author Url Publisher Url
Arkwright PD, Pumphrey RS, Woods CN, McDowell G, Pemberton PW, Summers CW. 2008. Clinical and laboratory parameters predicting severity and nature of allergic reactions after ingestion of nuts JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 121 :S214-S214 DOI Publisher Url
Dunn WB, Broadhurst DI, Deepak SM, Buch MH, McDowell G, Spasic I, Ellis DI, Brooks N, Kell DB, Neyses L. 2007. Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate METABOLOMICS, 3 :413-426 DOI Author Url Publisher Url
Byrne GJ, Hayden KE, McDowell G, Lang H, Kirwan CC, Tetlow L, Kumar S, Bundred NJ. 2007. Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer INTERNATIONAL JOURNAL OF ONCOLOGY, 31 :1127-1132 DOI Author Url Publisher Url
Byrne GJ, McDowell G, Agarawal R, Sinha G, Kumar S, Bundred NJ. 2007. Serum vascular endothelial growth factor in breast cancer ANTICANCER RESEARCH, 27 :3481-3487 Author Url
Al-Mowallad A, Kirwan C, Byrne G, McDowell G, Li C, Stewart A, Al-Qouzi A, Kumar S. 2007. Vascular endothelial growth factor-C in patients with breast cancer IN VIVO, 21 :549-551 Author Url
Patiar S, Kirwan CC, McDowell G, Bundred NJ, McCollum CN, Byrne GJ. 2007. Prevention of venous thromboembolism in surgical patients with breast cancer BRITISH JOURNAL OF SURGERY, 94 :412-420 DOI Author Url Publisher Url
Davis JRE, McNeilly JR, Norris AJ, Pope C, Wilding M, McDowell G, Holland JP, McNeilly AS. 2006. Fetal gonadotrope cell origin of FSH-secreting pituitary adenoma - insight into human pituitary tumour pathogenesis CLINICAL ENDOCRINOLOGY, 65 :648-654 DOI Author Url Publisher Url
McDowell G, Temple I, Li C, Kirwan CC, Bundred NJ, McCollum CN, Burton IE, Kumar S, Byrne GJ. 2005. Alteration in platelet function in patients with early breast cancer ANTICANCER RESEARCH, 25 :3963-3966 Author Url
McDowell G, Gupta S, Dellerba M, Coppinger T, Levy RD, Keevil B. 2004. Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with chronic cardiac failure ANNALS OF CLINICAL BIOCHEMISTRY, 41 :491-493 DOI Author Url Publisher Url
McDowell G, Temple I, Kirwan CC, Burton IE, Bundred NJ, Byrne GJ. 2004. Alteration in Platelet Function in Early Breast Cancer Clinical Science, 106 :10P-10P DOI Publisher Url
McDowell G, Mitsides N, Aziz N, Bubtana A, Keevil BG, Wood GNI. 2004. Prediction of Outcome in Pre-Dialysis Renal Failure. a 2 Year Prospective Study Utilising Pregnancy Associated Plasma Protein a as a Marker Clinical Science, 106 :11P-11P DOI Publisher Url
Buckley MG, Liversedge SN, Dean JD. 2003. Investigative Survey into Diabetes Services in Primary Care: Are We Prepared for the Diabetes National Service Framework (Nsf) Clinical Science, 104 :4P-4P DOI Publisher Url
McDowell G, Bubtana A, Wood GNI, Keevil BG. 2003. Circulating Levels of Thrombospondin and Cellular Adhesion Molecules during Haemodialysis in Patients with Chronic Renal Impairment Clinical Science, 104 :15P-15P DOI Publisher Url
Wood GNI, Keevil B, Gupta J, Foley R, Bubtana A, McDowell G, Ackrill P. 2003. Serum troponin T measurement in patients with chronic renal impairment predicts survival and vascular disease: a 2 year prospective study NEPHROLOGY DIALYSIS TRANSPLANTATION, 18 :1610-1615 DOI Author Url Publisher Url
McDowell G, Walker A, Yonan N, Deiranya A, Keevil B. 2003. Clinical Significance of the Analysis of Pancreatic Enzymes in Patients following Cardiac Surgery Clinical Science, 104 :14P-15P DOI Publisher Url
McDowell G, Gupta S, Dellerba M, Ward C, Levy RD, Keevil BG. 2003. Plasma Levels of Dimeric Pyruvate Kinase, a Novel Biochemical Marker of Energy Metabolism, in Patients with Chronic Cardiac Failure Clinical Science, 104 :15P-15P DOI Publisher Url
McDowell G, Patterson C, Maguire S, Shaw C, Nicholls DP, Hall C. 2002. Variability of Nt-proANP and C-ANP EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 32 :545-548 DOI Author Url Publisher Url
McDowell G, Keevil B. 2001. Use of Anti-Platelet Agents to Prevent in Vitro Activation During Sampling for Thrombospondin Clinical Science, 101 :8P-8P DOI Publisher Url
McDowell G, Nicholls DP. 2000. The therapeutic potential of candoxatril, a neutral endopeptidase inhibitor, in humans CARDIOVASCULAR DRUG REVIEWS, 18 :259-270 DOI Author Url Publisher Url
Lovell SL, Maguire SM, Turtle F, McDowell G, Campbell NPS, Riley MS, Nicholls DP. 2000. Comparative physiological study of arbutamine with exercise in humans CLINICAL SCIENCE, 98 :489-494 DOI Author Url Publisher Url
LOVELL SL, MAGUIRE SM, TURTLE F, McDOWELL G, CAMPBELL NPS, RILEY MS, NICHOLLS DP. 2000. Comparative physiological study of arbutamine with exercise in humans Clinical Science, 98 :489-489 DOI Publisher Url
McDowell G, Cave M, Bainbridge A, Danton M, Shaw C, Buchanan KD, Wallwork J, Large S, Nicholls DP. 2000. Is the secretion of atrial natriuretic peptide in man under neural control? EUROPEAN HEART JOURNAL, 21 :498-503 DOI Author Url Publisher Url
Lovell SL, Stevenson H, Young IS, McDowell G, McEneaney D, Riley MS, Nicholls DP. 2000. Exhaled nitric oxide during incremental and constant workload exercise in chronic cardiac failure EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 30 :181-187 DOI Author Url Publisher Url
McDowell G, Nicholls DP. 1999. The endopeptidase inhibitor, candoxatril, and its therapeutic potential in the treatment of chronic cardiac failure in man Expert Opinion on Investigational Drugs, 8 :79-84 DOI Author Url Publisher Url
Lovell SL, McDowell G, McEneaney D, Riley MS, Nicholls DP. 1998. Exhaled Nitric Oxide during Exercise in Chronic Cardiac Failure in Man Clinical Science, 94 :8P-8P DOI Publisher Url
Seifer C, McNeill B, O'donnell M, Daly K, Kellett J, McGee HM, Montgomery AJ, O'callaghan D, Horgan JH, Mahon NG, Codd M, Brennan J, Egan B, McCann HA, Sugrue DD, Menown IBA, Patterson RSHW, McMechan SR, Hameed S, Adgey AAJ, Baird SH, McBride SJ, Trouton TG, Wilson C, McRedmond JP, Fitzgerald DJ, Crowley JJ, Tanguay JE, Santos RM, Stack RS, Keelan P, McKenna CJ, Aubuchon R, Camrud AR, Holmes DR, Schwartz RS, Wolff R, Edwards WD, Hanratty C, McAuley D, Young I, Murtagh G, O'keeffe B, Richardson G, Scott M, Chew EW, Bailie NA, Graham AMJ, O'kane H, Kwon HM, Ellis L, Virmani R, Noelke L, Wood AE, Javadpour H, Veerasingham D, O'kane D, Allen JD, Hennessy T, Johnson P, Hildick-Smith D, Winter E, Shapiro L, Lerman A, McGrath LT, Passmore P, Silke B, Nugent AG, McGurk C, Maguire S, Johnston GD, Lovell SL, McDowell G, McEneany D, Riley MS, Nicholls DP, Gilligan D, Sargent D, Dan D, Elam G, Rhee B, Keane D, Zhou L, McGovern B, Garan H, Ruskin J, O'shea JC, Tan HC, Zidar JP, O'keeffe DB, Graffin S, Fitzsimmons D, Brown S, Duff D, Denham B, Woods F, Neligan M, Oslizlok P, Connolly CK, Danton MHD. 1998. Irish cardiac society - Proceedings of annual general meeting held 1st November, 1997 Irish Journal of Medical Science, 167 :5-25 DOI Publisher Url
Steele IC, McDowell G, Moore A, Campbell NPS, Shaw C, Buchanan KD, Nicholls DP. 1997. Responses of atrial natriuretic peptide and brain natriuretic peptide to exercise in patients with chronic heart failure and normal control subjects EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 27 :270-276 DOI Author Url Publisher Url
McDowell G, Coutie W, Shaw C, Buchanan KD, Struthers AD, Nicholls DP. 1997. The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 43 :329-332 DOI Author Url Publisher Url
McDowell G, Hosseinpour R, Shaw C, Nicholls DP, Rowlands E, Large SR. 1996. Atrial Natriuretic Peptide, Atrial Fibrillation and Mitral Surgery with and without Surgical Cardioversion to Sinus Rhythm Clinical Science, 90 :29P-30P DOI Publisher Url
McDowell G, Shaw C, Buchanan KD, Nicholls DP. 1996. A- and B-Type Natriuretic Peptides Bind to a Plasma Protein Clinical Science, 90 :9P-9P DOI Publisher Url
Nicholls DP, Onuoha GN, McDowell G, Elborn JS, Riley MS, Nugent AM, Steele IC, Shaw C, Buchanan KD. 1996. Neuroendocrine changes in chronic cardiac failure BASIC RESEARCH IN CARDIOLOGY, 91 :13-20 DOI Author Url Publisher Url
Mbeta E, McDowell G, West J, Hill JE, Sankaranarayanan R. Wearable cuffless blood pressure monitoring devices: A commentary British Journal of Community Nursing, 29 :468-472 DOI Author Url Publisher Url Public Url
Editorial/letter to the editor
Mills MT, McDowell G, Lip GYH. 2024. Predicting future atrial fibrillation: risk factors, proteomics and beyond. Heart (British Cardiac Society), :heartjnl-2024 DOI Author Url Publisher Url
Huang B, McDowell G, Rao A, Lip GYH. 2024. Mineralocorticoid receptor antagonist for chronic kidney disease, risk or benefit? Journal of hypertension, 42 :396-398 DOI Author Url Publisher Url
Ding WY, McDowell G, Lip GYH. 2021. Utilizing biomarkers in atrial fibrillation: the pros and cons CARDIOVASCULAR RESEARCH, DOI Author Url Publisher Url
Conference publication
Mbeta E, Sankaranarayanan R, Austin P, Penson P, Lip G, McDowell G. 2024. 163 Prediction of outcomes in patients with hypertension using clinical laboratory biomarkers - a real-world analysis using a global federated database Heart failure, British Cardiovascular Society Annual Conference, ‘Back to the patient’, 3–5 June 2024 :A175.1-A175 DOI Publisher Url
Chen Y, Gerra L, Gue Y, McDowell G, Boriani G, Zheng Y, Lip G. 2024. 126 Identifying at-risk patients for atrial high-rate episodes by machine learning Cardiac rhythm management, British Cardiovascular Society Annual Conference, ‘Back to the patient’, 3–5 June 2024 :A130-A130 DOI Publisher Url
Mcdowell G, Moore L, Buckley B, Austin P, Lip G, Rao A. 2023. #4779 CARDIAC BIOMARKERS FOR THE PREDICTION OF INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS Nephrology Dialysis Transplantation, 38 DOI Publisher Url
Mcdowell G, Downey R, Buckley B, Austin P, Lip G, Rao A. 2023. #4787 VITAMIN D AND PARATHYROID HORMONE PREDICT INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS Nephrology Dialysis Transplantation, 38 DOI Publisher Url
Davies E, Mcdowell G, Buckley B, Austin P, Lip G, Rao A. 2023. #4789 ROUTINE CARDIAC BIOMARKERS FOR THE PREDICTION OF INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS WITH GLOMERULONEPHRITIS: A REAL-WORLD ANALYSIS Nephrology Dialysis Transplantation, 38 DOI Publisher Url
McDowell G, Buckley B, Rao A, Austin P, Lip G. 2023. Prediction of incident major adverse cardiac events in patients starting haemodialysis for end stage kidney disease, using clinical laboratory cardiac biomarkers: a real world analysis HEART, British Cardiovascular Society 109 :A242-A243 DOI Publisher Url
McDowell G. 2023. A MILDLY ELEVATED TROPONIN PREDICTS 30-DAY OUTCOME IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH CHEST PAIN WHERE ACUTE MYOCARDIAL INFARCTION IS EXCLUDED. A REAL-WORLD ANALYSIS HEART, British Cardiovascular Society 109 :A68-A68 DOI Publisher Url
Mcdowell G, Downey R, Buckley B, Austin P, Lip G, Rao A. 2023. VITAMIN D AND PARATHYROID HORMONE PREDICT INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS NEPHROLOGY DIALYSIS TRANSPLANTATION, European Renal Association 38 :I66-I67
Davies E, Mcdowell G, Buckley B, Austin P, Lip G, Rao A. 2023. ROUTINE CARDIAC BIOMARKERS FOR THE PREDICTION OF INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS WITH GLOMERULONEPHRITIS: A REAL-WORLD ANALYSIS NEPHROLOGY DIALYSIS TRANSPLANTATION, European Renal Association 38 :I381-I382
Bucci T, Sagris D, Harrison S, Pastori D, Ntaios G, Mcdowell G, Buckley BJR, Lip GYH. 2023. C-reactive protein in Stroke-Heart-Syndrome: a propensity-matched analysis of a global federated health network EUROPEAN HEART JOURNAL, European Society of Cardiology COngress 44 DOI Publisher Url
Mcdowell G, Moore L, Buckley B, Austin P, Lip G, Rao A. 2023. CARDIAC BIOMARKERS FOR THE PREDICTION OF INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS NEPHROLOGY DIALYSIS TRANSPLANTATION, European Renal Association 38 :I814-I815
McDowell G, McMullen A, Al-Mashali M, Austin C, Dempsey-Hibbert N, Stout M, Slevin M, Body R. 2020. 35 The (troponin) – manchester acute coronary syndrome rules in the emergency department systematic review and meta-analysis Acute Coronary Syndromes & Interventional Cardiology, Abstracts from the British Cardiovascular Society Annual Conference 2020 :A31-A32 DOI Publisher Url
Victor K, Bangash F, Stylianidis V, Hancock J, Monaghan M, Piper S, Byrne J, McDowell G, Redwood S, McDonagh T, Prendergast B, Carr-White G. 2020. 86 Mitral regurgitation in acute heart failure: prevalence and response to treatment Heart Failure, Abstracts from the British Cardiovascular Society Annual Conference 2020 :A67.1-A67 DOI Publisher Url
Victor K, Bangash F, Stylianidis V, Hancock J, Monaghan M, Piper S, Byrne J, McDowell G, Redwood S, McDonagh T, Prendergast B, Carr-White G. 2020. Mitral regurgitation in acute heart failure: prevalence and response to treatment EUROPEAN HEART JOURNAL, 41 :1216-1216
McDowell G, Almashali M, Morris N, Body R. 2019. BEST-HEART SCORE: A RE-EVALUATION OF THE HEART SCORE IN THE ERA OF POINT OF CARE TROPONIN TESTING HEART, 105 :A127-A128 DOI Publisher Url
Campbell D, Pereira EG, McDowell G. 2014. Ontology Driven Framework for Personal mHealth Application Development 2014 EIGHTH INTERNATIONAL CONFERENCE ON NEXT GENERATION MOBILE APPS, SERVICES AND TECHNOLOGIES (NGMAST), 8th International Conference on Next Generation Mobile Apps, Services and Technologies (NGMAST) :320-325 DOI Author Url Publisher Url
Books (authored)
Slevin M, McDowell G. 2015. Handbook of vascular biology techniques :1-477 DOI Publisher Url
Chapters
McDowell G, Body R, Kirwan C, Byrne G, Slevin M. 2015. A scheme for the development and validation of enzyme linked immunosorbent assays (ELISA) for measurement of angiogenic biomarkers in human blood Handbook of Vascular Biology Techniques :453-463 DOI Publisher Url
Slevin M, Carroll M, Murgatroyd C, McDowell G. 2014. Biophysical and molecular targets Cardiac Arrhythmias: From Basic Mechanism to State-of-the-Art Management 9781447153160 :335-343 DOI Publisher Url
Slevin M, Baldellou M, Hill E, Alexander Y, McDowell G, Murgatroyd C, Carroll M, Degens H, Krupinski J, Rovira N, Chowdhury M, Serracino-Inglott F, Badimon L. 2014. Novel Methods for Accurate Identification, Isolation, and Genomic Analysis of Symptomatic Microenvironments in Atherosclerotic Arteries CEREBRAL ANGIOGENESIS: METHODS AND PROTOCOLS 1135 :289-305 978-1-4939-0320-7 DOI Publisher Url
McDowell G. 2012. Nanomedicine and the treatment of coronary in-stent restenosis - a clinical review Current Advances in the Medical Application of Nanotechnology :32-42 DOI Publisher Url
Body R, Slevin M, McDowell G. Biomarkers of Atherosclerosis and Acute Coronary Syndromes - A Clinical Perspective Traditional and Novel Risk Factors in Atherothrombosis InTech 9789535105619 DOI Publisher Url
Membership of professional bodies:
Fellow, European Society of Cardiology. 2014
Fellow, Royal College of Pathologists. 2008
Research Grants Awarded:
Alder Hey Children's Kidney Fund, Evaluating the lipidomic profile in glomerulonephritis as a bridging biomarker for paediatric extrapolation of cardiovascular disease risk., Grant value (£): 157186.22.
MS Society, Cardiovascular outcomes and risk factors for people with multiple sclerosis: Cardio-MS, Dr Ben Buckley; Dr Azmil Abdul-Rahim; Dr Stephanie Harrison; Dr Linsay McCallum; Dr Garry McDowell; Mrs Karen Parker; Dr Leona Ritchie; Prof Dr Carolyn Young, Grant value (£): 49,975.73.
The Dowager Countess Eleanor Peel Trust, A pilot study evaluating novel cardiovascular biomarkers in patients with kidney disease., Grant value (£): 19000.
Other Professional Activity:
External Examiner - Biomedical Science, Queens University Belfast.
External Examiner - MSc Biomedicine, Lancaster University.
External collaboration:
National School of Healthcare Science., Accreditation Panel Chair.